Ken Richardson is credited with discovering one of the most important breakthroughs in the history of anti-fungal research, fluconazole (Diflucan®), the world’s leading antifungal drug for human use.
Who discovered fluconazole?
Fluconazole was patented by Pfizer in 1981 in the United Kingdom and came into commercial use in 1988.
Who invented antifungal drugs?
One of the most famous tales in the history of American medical science is the long-distance collaboration of Elizabeth Lee Hazen (1885-1975) and Rachel Fuller Brown (1898-1980), who developed and patented a wonder drug of the 20th century: the world’s first successful fungus-fighting antibiotic.
What is fluconazole made from?
DIFLUCAN Tablets contain 50, 100, 150, or 200 mg of fluconazole and the following inactive ingredients: microcrystalline cellulose, dibasic calcium phosphate anhydrous, povidone, croscarmellose sodium, FD&,C Red No. 40 aluminum lake dye, and magnesium stearate.
What is the brand name of fluconazole?
Fluconazole is used to treat vaginal yeast infections. It works by stopping the growth of common types of vaginal yeast (fungus). This medication belongs to a class of drugs called azole antifungals. Fluconazole is available under the following different brand names: Diflucan.
How safe is fluconazole?
A prescription-event monitoring (PEM) study has confirmed that fluconazole, a bis-triazole oral antifungal drug, is a safe and effective treatment for vaginal candidiasis. Useful information was available on 15,015 questionnaires returned by general practitioners.
Is fluconazole safe for liver?
The severity of liver injury from fluconazole ranges from mild and transient enzyme elevations to clinically apparent hepatitis to acute liver failure and death. Most patients recover with stopping fluconazole, but resolution may be slow requiring 3 to 4 months. Rechallenge may lead to recurrence and should be avoided.
Which is the best antifungal cream?
- Clotrimazole (Lotrimin AF) cream or lotion.
- Miconazole (Micaderm) cream.
- Selenium sulfide (Selsun Blue) 1 percent lotion.
- Terbinafine (Lamisil AT) cream or gel.
- Zinc pyrithione soap.
What is the best medicine for fungi?
Antifungal creams, liquids or sprays (also called topical antifungals) These are used to treat fungal infections of the skin, scalp and nails. They include clotrimazole, econazole, ketoconazole, miconazole, tioconazole, terbinafine, and amorolfine. They come in various different brand names.
Which azole is best?
Major developments in research into the azole class of antifungal agents during the 1990s have provided expanded options for the treatment of many opportunistic and endemic fungal infections. Fluconazole and itraconazole have proved to be safer than both amphotericin B and ketoconazole.
Can I take fluconazole every day?
You usually take fluconazole for a short time to clear an infection. If you have a serious infection, you may need to take fluconazole long term. It is safe to take for a long time if your doctor has advised you to. If you take fluconazole long term, your doctor may ask you to have regular blood tests.
What does fluconazole do in the body?
Fluconazole works by blocking the ability of the fungi Candida and Cryptococcus to reproduce. For people with infections from these fungi, this drug helps to get rid of the infection. For people at higher risk of candidiasis, it helps to prevent infection.
What are side effects of fluconazole?
- Chills.
- clay-colored stools.
- difficulty with swallowing.
- fast heartbeat.
- general feeling of tiredness or weakness.
- hives, itching, or skin rash.
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals.
- light-colored stools.
Is one fluconazole pill enough?
One single oral dose is usually sufficient to treat vaginal candidiasis. Can be given as a single daily dose. The absorption of fluconazole is not affected by food.
What is the safest oral antifungal?
Fluconazole, and itraconazole are the preferred oral agents. Various dosing regimens have been used. Fluconazole has been offered as a single 150- to 300-mg weekly dose for 2-4 weeks and is the safest oral agent.
Can I buy fluconazole over the counter?
It works by killing yeast and fungi. Fluconazole is available on prescription, and it can also be bought at pharmacies, without a prescription, for the treatment of vaginal thrush.