Is fluconazole a hazardous drug?
Rare cases of serious liver damage and allergic reactions have been reported. There have been reports of multiple congenital abnormalities in infants whose mothers were being treated for 3 or more months with high dose (400-800mg/day) fluconazole.
What characteristics make a drug hazardous?
Hazardous Drug: Defined by the American Society of Health System Pharmacists in 1990 as being a drug which displays one or more of the following characteristics: genotoxicity, carcinogenicity, teratogenicity or fertility impairment, or serious organ or other toxic manifestation at low doses in experimental animals or …
What are the three types of hazardous drugs?
DHHS (NIOSH) Publication No.
The format for the 2014 list was revised to include three groups of hazardous drugs: (1) Antineoplastic drugs, (2) Non-antineoplastic hazardous drugs, and (3) Drugs with reproductive effects.
Is valproic acid a hazardous drug?
Valproic acid may cause serious or life-threatening damage to the pancreas. This may occur at any time during your treatment. If you experience any of the following symptoms, call your doctor immediately: ongoing pain that begins in the stomach area but may spread to the back nausea, vomiting, or loss of appetite.
How do I dispose of fluconazole?
1. Remove the medicine from its original container and mix it with an undesirable substance, such as used coffee grounds or kitty litter. 2. Place the mixture in a sealable bag, empty bag, or other container to prevent medicine from leaking or breaking out of a garbage bag.
How do you handle hazardous drugs?
When possible, avoid cutting, crushing, or otherwise manipulating pills or capsules. This might produce powder that can contaminate a workplace and may expose workers. When manipulating hazardous drugs, use effective engineering controls and personal protective equipment.
Is progesterone a hazardous drug?
Progesterone is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in ex- perimental animals.
Is pentamidine a hazardous drug?
Respiratory care practitioners administer aerosolized drugs, such as pentamidine and various antibiotics, to treat respiratory infections. At the time of the survey, pentamidine was classified by NIOSH as a hazardous drug with rigorous safe handling guidelines.
What PPE is required for hazardous drugs?
Wear Personal Protective Equipment (PPE) during handling activities based on the HML PPE Chart. Examples include gloves, hazardous gown (chemo gowns), face shields, goggles (face shields alone do not provide adequate eye protection), n-95 mask and/or powered air-purifying respirator (PAPR).
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What drugs are hazardous?
Hazardous drugs include those used for can- cer chemotherapy, antiviral drugs, hormones, some bioengineered drugs, and other miscella- neous drugs.
Is risperidone a hazardous drug?
NIOSH has determined it is unlikely that risperidone (Risperidal®) poses a carcinogenic, reproductive, or developmental hazard to workers in a healthcare setting and is no longer considered a hazardous drug by NIOSH.
What is a Group 2 hazardous drug?
• Group 2: Non-antineoplastic drugs that meet. one or more of the NIOSH criteria for a. hazardous drug. • Group 3: Drugs that primarily pose a. reproductive risk to men and women who are.
Is valproic acid good for anxiety?
It has been shown that valproic acid reduces anxiety symptoms in a 12-week open-label study in patients with social anxiety disorder [6. Valproic acid for the treatment of social anxiety disorder.
Does valproate cause liver damage?
More importantly and not uncommonly, valproate can cause several forms of clinically apparent hepatotoxicity. Indeed, more than 100 fatal cases of acute or chronic liver injury due to valproate have been reported in the literature.
What are the long term effects of valproic acid?
There is no evidence that long-term use of valproic acid will cause gradual damage to the liver. Another rare reaction to valproic acid is a disorder of the pancreas. Occasionally it is so severe that bleeding and death can occur.